WebJun 1, 2009 · atf3 protein represents one of the 53 basic leucine zipper (b-Zip) transcription factors in human and is composed of 181 amino acids with putative basic leucine zipper structure. The leucine zipper region is responsible for homo- or heterodimer formation with other member of bZip family proteins.
CHOP-ATF3 complex SGD
WebApr 12, 2024 · At the same time, phosphorylated eIF2α also specifically increases the activating transcription factor 4 (ATF4) level, which subsequently increases the CAAT/enhancer-binding protein homologous protein level (CHOP) [ 8] and tribbles 3 (TRB3) [ 9 ]. CHOP is another transcription factor. WebDec 2, 2024 · ATF4, ATF3, CHOP, and BiP were greatly induced by TN and PRMT1 inhibition further elevated their expression except BiP. Fura greatly enhanced transcripts … days inn phoenix north
ATF3 (activating transcription factor 3)
Neurodegenerative diseases have an underlying similarity in progressive neuronal dysfunction and neuronal cell death. Protein misfolding has been implicated in the pathogenesis, for example, the accumulation of misfolded proteins such as β-amyloid, α-synuclein and huntingtin is apparently associated with selective … See more Diabetes is characterized by hyperglycemia due to reduced insulin secretion and impaired insulin action. Excessive loss of β-cells is known to be a cause of diabetes, and apoptosis is the main mode of … See more Depletion of glucose, oxygen and ER Ca2+, which is a characteristic feature of tissue ischemia, is strongly associated with ER stress. … See more WebApr 4, 2024 · Salermide induces expression of ATF4, and ATF4 up-regulates ATF3 and subsequently modulates CHOP which leads to apoptosis in human cancer cells. ATF3 expression is a surrogate of malignancy (or pre-malignancy) in keratinocytic epith-elial proliferations and thus helps distinguish squamous cell carcinoma from other cutaneous … WebIn G6PI-evoked arthritis ATF3 is upregulated after immunization before inflammation becomes evident, raising the possibility that part of the hyperalgesia is caused by … days inn pictures