WebSTATISTICS IN MEDICINE Statist. Med. 2007; 26:2465–2478 ... testing strategy in the analysis of a clinical trial with multiple objectives. In this trial the first ... ij=Fi−1, the tree … WebGatekeeping is a prominent strategy for handling the multiple testing problem, and has been proven to keep the required sample sizes in animal studies comparatively low. Therefore, it is a suitable approach to a compromise between the Three Rs principle of reduction and the appropriate handling of the multiplicity issue in animal trials with a ...
Gatekeeping procedures in dose–response ... - Wiley Online Library
Weballel gatekeeping strategy for which the initial critical values of F 1;F 2 and F 3 are respectively 4 =5; =10 and =10 and except for transferring to F 2, 1=5 of the criti-cal value of F 1 can be passed down to F 3 if at least one hypothesis is rejected in F 1. Figure 3 (b) illustrates the family-based graph of this parallel gatekeep strategy. As WebTitle: Gatekeeping Strategies for Avoiding False-Positive Results in Clinical Trials With Many Comparisons Author: American Medical Association Keywords how long are people symptomatic with covid
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WebJul 14, 2003 · Statistics in Medicine. Volume 22, Issue 15 p. 2387-2400. Research Article. ... Efficient ‘gatekeeping strategies’ for multiplicity problems of this kind are developed. One family of hypotheses (comprising the primary objectives) is treated as a ‘gatekeeper’, and the other family or families (comprising secondary and tertiary objectives ... WebNov 10, 2016 · The gatekeeping strategy is a general approach dev eloped specifically to test pre- ... statistics, it is possible to further improve the proposed procedure. 22. Acknowledgments. WebMay 15, 2005 · Read "The application of enhanced parallel gatekeeping strategies, Statistics in Medicine" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. ... The parallel gatekeeping strategy proposed by Dmitrienko et al. (Statist. Med. 2003; 22:2387–2400) … how long are people usually engaged