Phenytoin folate deficiency
Possible interactions include: 1. Anticonvulsants.Taking folic acid with fosphenytoin (Cerebyx), phenytoin (Dilantin, Phenytek) or primidone (Mysoline) might decrease the drug's concentration in your blood. 2. Barbiturates.Taking folic acid with a drug that acts as a central nervous system depressant (barbiturate) … See more Folate (vitamin B-9) is important in red blood cell formation and for healthy cell growth and function. The nutrient is crucial during early pregnancy to reduce the risk of birth … See more When used orally at appropriate doses, folic acid is likely safe. Oral use of folic acid can cause: 1. Bad taste in your mouth 2. Nausea 3. Loss of … See more Research on use of folate and oral folic acid supplements for specific conditions shows: 1. Birth defects.Research has shown that folic acid … See more WebAbstract. The nutrient-drug interaction between folate and phenytoin is a two-way interaction. Folate deficiency resulting from long-term phenytoin therapy is a common occurrence, but progression of the deficiency to a megaloblastic anemia is rare. However, there are data to suggest nonanemic folate deficiency may be detrimental to the patient.
Phenytoin folate deficiency
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WebFolate deficiency resulting from long-term phenytoin therapy is a common occurrence, but progression of the deficiency to a megaloblastic anemia is rare. However, there are data … WebPhenytoin may cause swelling and bleeding of the gums. Massage your gums and brush and floss your teeth regularly to minimize this problem. See your dentist regularly.
WebMar 9, 2011 · The study authors now plan to investigate the genetic and nutritional factors that underlie folate and vitamin B 12 deficiency in patients treated with AEDs. “We will … WebMay 9, 2024 · A case of a patient who developed symptomatic phenytoin-induced folic acid deficiency is reported. Folate supplementation of 5 mg/d was followed by a decrease of …
WebFolate deficiency can be drug-induced and should be considered in patients treated with methotrexate, phenytoin, trimethoprimand pyrimethamine. Increased folate requirements are associated with ... WebSeveral studies revealed that PHT could reduce serum levels of folate and vitamin B12, [11,12] while folic acid and vitamin B12 are cofactors to support the converting of homocysteine to methionine. [13,14] Thus, long-term use of PHT may lead to the emergence of hyperhomocysteinaemia.
WebFeb 17, 2024 · Megaloblastic and macrocytic anemias due to folate deficiency: Oral: 1 to 5 mg once daily (Cook 2014); doses up to 15 mg once daily have also been recommended …
WebJun 27, 2024 · Folic acid deficiency can occur subsequent to vitamin B-12 deficiency due to an impairment of methionine synthase resulting in the trapping of folate as methyltetrahydrofolate whereby methylene THFA accumulates in serum leading to folate trap phenomenon and increased urinary excretion of folate. ... phenytoin, trimethoprim … left ventricular outflow obstruction causesWebA severe deficiency may result in a red and sore tongue, diarrhea, a reduced sense of taste, depression, confusion, and dementia. If a pregnant woman has folate deficiency, the risk … left ventricular outflow tract mean gradientWebConclusions: Folic acid supplementation should be initiated each time phenytoin therapy commences because of the hypothesized cofactor mechanism, decreased adverse … left ventricular non compaction meanWebFolate deficiency means you have a lower-than-normal amount of folic acid, a type of vitamin B, in your blood. Causes Folic acid (vitamin B9) works with vitamin B12 and vitamin C to help the body break down, use, and make new proteins. The vitamin helps form red and white blood cells. left ventricular outflow tract lvotWebFeb 23, 2024 · The decrease of Folate concentration was due to the effect of Phenytoin mainly on inhibiting the intestinal absorption of Folate 1. The result showed that the mean … left ventricular outflow tract mean velocityWebJun 28, 2016 · Folic acid supplementation should be initiated each time phenytoin therapy commences because of the hypothesized cofactor mechanism, decreased adverse effects associated with folate deficiency, and better seizure control with no perturbation of phenytoin pharmacokinetics. left ventricular perfusion abnormalWebWhether they produce clinically relevant deficiency of B vitamins has rarely been assessed. We obtained B-vitamin levels in patients who were being converted from an inducing AED (phenytoin or carbamazepine) to a non-inducing AED (levetiracetam, lamotrigine, or topiramate), with measurements both before and ≥ 6 weeks after the switch. left ventricular outflow tract icd 10 code