Refractory to platelet transfusion
WebMay 1, 2001 · In many such patients refractory to random donor platelet transfusion and without histocompatible donors or siblings, multiple courses of intensive postremission … Web2 days ago · A refractory status is defined as an inadequate increment in the posttransfusion platelet count determined 1 hour after transfusion. 1 The rapid removal of transfused platelets from the circulation of the recipient leads to transfusion failure and is associated with poor outcomes. 2 At present, patients with platelet refractoriness are …
Refractory to platelet transfusion
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WebAlthough the majority of platelet transfusion-refractory cases are due to nonimmune causes, a significant minority are caused by alloimmunization against Class I human leukocyte antigens (HLAs) or human platelet antigens (HPAs). Such platelet transfusion-refractory patients can be effectively managed with appropriate antigen-negative products. WebCauses of Refractoriness to Platelet Transfusion Non-immune causes: Fever, infection, sepsis; Diffuse endothelial injury; Medications; Hypersplenism; Microangiopathy ; …
WebPlatelet refractoriness is a complication of platelet transfusion that affects variable proportions of patients, mostly depending on their diagnosis, previous immunologic … WebObjective: A few patients in neonatal intensive care units (NICU) receive numerous platelet transfusions. These patients can become refractory, defined as transfusions of ≥10 mL/kg failing to increase the platelet count by at least 5000/µL. Causes of, and best treatments for, platelet transfusion refractoriness in neonates have not been defined.
WebMar 24, 2009 · injury and immunization to platelet antigens. A post-transfusion platelet count should be obtained 10 minutes to 1 hour after transfusion for best assessment of transfusion effectiveness. Transfusion of one platelet pool (i.e. 5-pack) or one unit of apheresis platelets will typically increase the platelet count of an adult by 20,000 – … WebNov 28, 2024 · The incidence of alloantibody-mediated refractoriness to platelet transfusion can be decreased in patients with acute myeloid leukemia (AML) receiving induction chemotherapy when both platelet and RBC products are leukoreduced before transfusion. It is therefore appropriate to provide leukoreduced blood products to patients with AML …
WebPlatelet refractoriness caused by nonimmune and immune mechanisms remains a major issue when repeated transfusions are required. HLA matching and platelet crossmatching are initial strategies to address immune platelet refractoriness. Antifibrinolytic agents may be useful adjuncts to platelet transfusion in the bleeding or platelet refractory ...
WebA challenging complication raised from multiple platelet transfusions is the platelet transfusion refractoriness (PTR) that leads to increased rates of morbidity and mortality. 53 PTR is defined as the lack of adequate post-transfusion platelet count increment. One therapeutic unit of platelets should increase the platelet count by 35,000/µL ... unearthed ghosts of stonehengeWebassistance ordering testing, interpreting the results, and/or deciding what type(s) of special platelet products to order. The Medical Director may also help identify additional means by which to support refractory patients’ platelet transfusion-related needs. Vitalant to Complete DIN/ Component Codes HLA Match PLT XM Unit Status ABO/Rh CMV unearthed homes pty ltdWebAug 19, 2011 · The traditional platelet transfusion policy adopted in the 1980s of ensuring that the patient’s platelet count remained above 20,000 platelets per microlitre 2 was consistent with the above consideration. More recently, this level was reduced to 10,000 platelets per microlitre in stable onco-haematology recipients based on several … unearthed in chinaWebMay 12, 2024 · Refractoriness to platelet transfusion ● Anti-HLA – The most common types of epitopes are from the human leukocyte antigen (HLA) system, which are present on... ● Anti-HPA – Less commonly seen epitopes in platelet immune refractoriness are human … unearthed home furniture madison wiWebPlatelet transfusions are commonly used for prophylaxis and treatment of bleeding. After a transfusion, an increment or "boost" is expected to occur. While a number of factors can … unearthed houseWebrefractoriness to platelet transfusion. For RhD-negative female children or women of child-bearing potential who have received RhD-positive platelets, Rh immunoglobulin should probably be given to prevent immuniza-tion to the RhD antigen. Providing platelet support for the alloimmunized refractory patients with ABO- unearthed in china fossils of feathered gmatWebJan 1, 2007 · Platelet transfusions. Enrolled. Female patients. Possible prior sensitization*. Platelet transfusions Median (range). Platelet refractoriness†P= .001. Anti-A/B‡. Anti-HLA. Platelet-specific. *Possible prior sensitization after pregnancy/transfusion. †1-hour post-transfusion corrected count increment less than 4500. unearthed i 2016– watch online