Taurocholate cotransporting polypeptide
WebSep 1, 2006 · Previously, we constructed polarized LLC-PK1 cells that express both a major bile acid uptake transporter human Na+/taurocholate cotransporting polypeptide … WebMar 1, 2024 · Introduction. Defects in genes encoding for the export pumps on the canalicular side of hepatocytes are well known and documented. They result in …
Taurocholate cotransporting polypeptide
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WebJul 3, 2024 · The Na + /taurocholate cotransporting polypeptide (NTCP) and the organic cation transporter 1 (OCT1) are hepatic uptake transporters located on the basolateral membrane of hepatocytes. They are essential for bile acid homeostasis and the disposition of antidiabetic drugs. WebAug 10, 2024 · Chronic hepatitis B, C and D virus (HBV, HCV and HDV) infections are a major cause of liver disease and cancer worldwide. Despite employing distinct replication …
WebMay 1, 2015 · Sodium taurocholate cotransporting polypeptide (NTCP), a key bile acid transporter expressed in liver, was recently identified as a critical receptor for viral entry of … WebThe Na+-taurocholate cotransporting polypeptide SLC10A1 (NTCP) plays a key role in this process as the major transporter of conjugated bile salts from the plasma compartment …
WebApr 13, 2024 · In the paper “Hepatic Expression of the Na +-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation”, Tremmel et al. investigated interindividual patient’s hepatic SLC10A1/NTCP expression using various omics technologies and found that the variability in NTCP expression is multifactorial with the … WebNov 13, 2012 · Here, by using near zero distance photo-cross-linking and tandem affinity purification, we revealed that the receptor-binding region of pre-S1 specifically interacts …
WebMay 17, 2024 · Yan, H. et al. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife 1 , e00049 (2012). Article PubMed …
WebMar 24, 2024 · Liver organoids derived from hiPSCs have been shown to be highly susceptible to HBV infection,52 as are liver organoids generated from primary hepatocytes.53,54 Liver organoids displayed high expression of the HBV entry receptor, the sodium-taurocholate cotransporting polypeptide52–54 (Table (Table1). 1). blistering firecat mtgWebIn 2012, sodium taurocholate cotransporting polypeptide (NTCP) was identified as the entry receptor of HBV. Based upon this groundbreaking discovery, a series of molecules have … free admin minecraft serverWebIn the liver, hepatocytes take up bile salts and secrete them again into bile for ongoing enterohepatic circulation. Uptake of bile salts into hepatocytes occurs largely in a sodium … blistering firecatWebNov 4, 2024 · The human Na +-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma … free admin roblox ban hammerWebSodium taurocholate cotransporting polypeptide is the primary basolateral conjugated bile acid transporter. Its deficiency is associated with long-lasting hypercholanemia. What Is … free administrative professional clipartWebApr 1, 2024 · The Na +-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1) is a hepatocyte-specific solute carrier, which plays an important role in … free admin template in theme wagonWebIntroduction. Sodium + /taurocholate cotransporting polypeptide (NTCP) is a multipass transmembrane protein expressed almost exclusively on the sinusoidal membranes of … free admin roblox thumbnail