2024 The irf family of transcription factors

The irf family of transcription factors

Author: knfu

August undefined, 2024

WebInterferon regulatory factors (IRF) are proteins which regulate transcription of interferons (see regulation of gene expression). Interferon regulatory factors contain a conserved N … WebApr 13, 2024 · The protein-protein interaction (PPI) analysis showed upregulated AP-1 transcription factors (JUN and FOS) among the top hub and bottleneck genes in RR-MS and ZIKV data. ... and IFN regulatory factor (IRF) family components . In the present study, inflammation was found overrepresented by the common enrichment of several …

IRF Family of Transcription Factors as Regulators of Host Defense

WebJul 28, 2009 · The IRF family encodes transcription factors that play important roles in immune defense, stress responses, reproduction, development, and carcinogenesis. Several times during their evolution, the IRF genes have undergone expansion and diversification. These genes were also completely lost on two separate occasions in large groups of … WebNov 1, 2012 · Interferon regulatory factor (IRF) family proteins were originally identified as a group of DNA-binding proteins that can be induced upon type I interferon (IFN) signaling … curve jeans tj maxx

Frontiers Therapeutic Targeting of IRFs: Pathway …

WebImmune cell development. IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive stimuli, including antigen receptor engagement, … WebThe TALE gene family is an important transcription factor family that regulates meristem formation, organ morphogenesis, signal transduction, and fruit development. A total of 24 … WebNov 16, 2012 · Together, these studies demonstrate that a cooperative complex formed by a monomer of the interferon regulatory factor (IRF) family of transcription factors and a heterodimer of the activator protein–1 (AP-1) Jun and B cell activating transcription factor (BATF) has a major role in lineage specification and function in cells of the immune system. dj502379

IRF7: activation, regulation, modification and function

The irf family of transcription factors

The Interferon (IFN) Class of Cytokines and the IFN Regulatory Factor …

WebSep 1, 2006 · The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs … WebA hallmark of the innate immune response is the induction of the type I IFN (IFN-α/β) that occurs on activation of the signal-transducing pattern recognition receptors (PRRs) of the …

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WebThe IRF family of transcription factors is involved in many aspects of the immune response . For instance, IRF‐1‐deficient mice fail to develop NK cells and are hyporesponsive to IFN‐γ. For instance, IRF‐1‐deficient mice fail to develop NK cells and are hyporesponsive to IFN‐γ. WebNov 1, 2012 · Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system.

WebJan 9, 2008 · The original discovery of the first two members of the interferon (IFN) regulatory factor (IRF) family, IRF1 and IRF2, opened up new avenues of research in immunity and oncogenesis, which we may call ‘the … WebThe IRF family of transcription factors is involved in many aspects of the immune response . For instance, IRF‐1‐deficient mice fail to develop NK cells and are hyporesponsive to …

WebSep 29, 2024 · The nine-member IFN regulatory factor (IRF) family, first discovered in the context of transcriptional regulation of type I IFN genes following viral infection, are pivotal for the regulation of the IFN responses. WebThe interferon regulatory factor (IRF) family of transcription factors consists of nine members in human and mice and control aspects of Toll-like receptor (TLR) signaling, hematopoietic differentiation, and oncogenesis, in addition to expression of interferons (IFNs) and IFN-inducible genes (Tamura et al., 2008).

WebJun 1, 2007 · The interferon regulatory factor (IRF) family of transcription factors play a vital role in the human innate antiviral immune responses with production of interferons (IFNs) as a hallmark outcome of activation. In recent years, IRF3 has been considered a principal early regulator of type I IFNs (TI-IFNs) directly downstream of intracellular ...

WebInterferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial … curve jnjWebInterferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial … curve jeans nzWebApr 8, 2024 · The KLF family is composed of at least 18 transcription factors. They are widely distributed in eukaryotes and involved in embryonic development, tissue and organ maturation, stem cell generation ... curve jeans tk maxxWebApr 12, 2024 · The AP2/ERF transcription factor family is one of the most important gene families in plants and plays a vital role in plant abiotic stress responses. Although … dj5 postal jeep for sale craigslistWebNov 30, 2012 · Members of the interferon-regulatory factor (IRF) proteins family were originally identified as transcriptional regulators of the Type I interferon system. Thanks to … dj4e-samplesWebIRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and … dj520110WebJan 5, 2010 · Nine interferon regulatory factors (IRFs) compose a family of transcription factors in mammals. Although this family was originally identified in the context of the type I interferon system, subsequent studies have revealed much broader functions performed by IRF members in host defense. In this review, we provide an update on the current … dj5177-100