2024 Tov-21g cisplatin

Tov-21g cisplatin

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August undefined, 2024

WebIn the TOV-21G model, baseline tumor volumes for the vehicle, cisplatin and NXP800 groups were 201.71, 205.66 and 202.20 mm 3, respectively; on Day 28, average tumor volumes were 399.84, 236.68 and 121.47 mm 3, respectively, representing increases in tumor volume of 98% for the vehicle control group and 15% for the cisplatin group, and a ... WebThe cells were reverse transfected and treated with cisplatin for 24 h, at 48 h after the reverse transfection. The data are shown as mean ± SD of triplicate experiments.

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WebTOV-21G devoid of FANCF expression, OV-90 and SKOV-3 were employed as examples of platinum-sensitive, ... Consistent with these cytotoxic profiles, cisplatin/mitomycin C, ... WebMay 11, 2024 · demonstrate that treatment of A2780, SKOV-3, and TOV-21G cells with -mangostin in combination with cisplatin can allow a reduction in cisplatin concentration while maintaining the same cytotoxic effect. Ovarian cancer cells release a variable number of exosomes into the microenvironment when exposed to -mangostin and/or cisplatin. inform 6.1

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WebTo cite this cell line use: TOV-21G (RRID:CVCL_3613) Comments. Group: Patented cell line. Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). Part of: COSMIC cell lines project. Part of: KuDOS 95 cell line panel. Part of: MD Anderson Cell Lines Project. Part of: OCCP ovarian cancer cell line panel. WebCisplatin is considered to be the most active platinum agent drug. Neoadjuvant (or induction) chemotherapy can be used for cervical cancer patients with locally advanced disease; this treatment is followed by radical surgery and/or radiation therapy. WebM MnP+Cisplatin. 0.5 . μ. M. Supplementary Figure 2. Synergistic effect of MnP and Platinum compounds on TOV 21G. Colony survival assay was performed after 24 hr treatment. (A) MnP. (B) Carboplatin. (C) Cisplatin. MnP and drugs were added at the same time. A. Extracellular H 2O 2 0 20. 40. 60. 80. 100. 120. inform 7 actions

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WebIn the TOV-21G model, baseline tumor volumes for the vehicle, cisplatin and NXP800 groups were 201.71, 205.66 and 202.20 mm 3, respectively; on Day 28, average tumor volumes were 399.84, 236.68 and 121.47 mm 3, respectively, representing increases in tumor volume of 98% for the vehicle control group and 15% for the cisplatin group, and a ... WebJul 1, 2024 · Erastin dose-dependently inhibited growth in TOV-21G cells, but not KOC-7C cells. Treatment of TOV-21G cells with erastin resulted in increase of ROS. Iron chelator deferoxamine (DFO) rescued growth inhibition induced by erastin in TOV-21G cells. Although cisplatin inhibited growth in TOV-21G cells, this inhibition was not rescued by … inform 6 ide inform6 manual

"WebCitation 49–53 The results suggest that compared to its free drug combination, nanoparticle mediated delivery of gemcitabine further enhanced synergistic interactions with cisplatin in different ovarian cancer subtypes including high drug-resistant cancer subtypes such as PA-1 teratocarcinoma and TOV-21G clear cell carcinoma. " - Tov-21g cisplatin

Tov-21g cisplatin

Morin decreases galectin-3 expression and sensitizes ovarian

WebMar 5, 2014 · Suppression of REV7 enhances cisplatin (CDDP) sensitivity in vivo. (a) Growth of inoculated tumors in nude mice with and without systemic CDDP treatment. REV7‐knockdown (shREV7) or control (shCont) ovarian clear cell carcinoma TOV‐21G cells (1 × 10 7) were used in this analysis. WebSep 8, 2024 · Cisplatin-resistant ES2 cells were generated by exposing the parental ES2 cells to increasing doses of cisplatin over a period of 5 months with gradual dose escalations every 3 weeks. Human specimens

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WebMar 30, 2024 · For cisplatin-treated TOV-21G cells, the IC50 value was 77.56 µM, while the same cytotoxic effect was obtained by treating the cells with the two drugs at a cisplatin concentration of 50 µM. A synergistic effect of α-mangostin and cisplatin was also observed on cisplatin-resistant SKOV-3 cells. WebSep 17, 2014 · A2780ADR and A2780CIS were challenged once a month with 100 nM Doxorubicin and 1 µM Cisplatin respectively. Short tandem repeat analysis The PowerPlex 16 System (Promega) was used according to the manufacturer's protocol using an ABI PRISM 3100 to generate an STR (Short tandem repeat) fingerprint of each cell line to …

WebNov 10, 2024 · Cisplatin, Carboplatinum, Doxorubicin, 5-Fluorouracil, Gemcitabine and Paclitaxel where purchased from Sigma-Aldrich, ... French female.17 The OV-90 cell line is Her2/neu + and like the clear cell line TOV-21G has a deletion at 3p24. Interestingly, this same locus has been found to be associated with breast WebATCC tov 21g cells lines Tov 21g Cells Lines, supplied by ATCC, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS ... Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3 ...

WebAug 17, 2024 · The ES-2 and TOV-21G cell lines were purchased from the Bioresource Collection and Research Center of the Food Industry Research and ... Cisplatin (Fresenius Kabi Oncology, Ltd.) and paclitaxel (Corden Pharma Latina S.P.A.) were provided by the Cancer Center National Cheng Kung University Hospital. Plasmid construction and site ... WebApr 13, 2024 · In addition, PLGA-PEG-based nanoparticles were used to encapsulate both cisplatin and wortmannin for the treatment of platinum-resistant ovarian cancer. 45 In this combination system, wortmannin, a phosphoinositide 3-kinase inhibitor, can potently block downstream DNA repair pathways that are involved in cisplatin resistance. 46,47 As a …

WebMay 11, 2024 · For cisplatin-treated TOV-21G cells, the IC50 value was 77.56 µM, while the same cytotoxic effect was obtained by treating the cells with the two drugs at a cisplatin concentration of 50 µM. A synergistic effect of α-mangostin and cisplatin was also observed on cisplatin-resistant SKOV-3 cells.

WebSep 28, 2024 · When TOV-21G cells were treated with morin and cisplatin simultaneously for 24 h (APP:1; Fig. 2a), there occurred a synergism at low concentrations of cisplatin (3.125–6.25 µM), an additive effect at a medium dose of cisplatin (12.5 µM), and an antagonism at high concentrations of cisplatin (25–50 µM). in form 96WebCompound Viability screens Drug sensitivity AUC (Sanger GDSC1) Drug sensitivity AUC (Sanger GDSC2) Drug sensitivity IC50 (Sanger GDSC1) Drug sensitivity IC50 (Sanger GDSC2) Drug sensitivity AUC (CTD^2) Drug sensitivity (PRISM Repurposing Primary Screen) Drug sensitivity AUC (PRISM Repurposing Secondary Screen) Drug sensitivity replicate-level … in form 56305Web2 days ago · In addition, PLGA-PEG-based nanoparticles were used to encapsulate both cisplatin and wortmannin for the treatment of platinum-resistant ovarian cancer. 45 In this combination system, wortmannin, a phosphoinositide 3-kinase inhibitor, can potently block downstream DNA repair pathways that are involved in cisplatin resistance. 46,47 As a … in form 65WebDec 26, 2024 · Purpose Assessment of miR-424-3p mimic capability to sensitize SK-OV-3 and TOV-21G ovarian cancer cells to cisplatin by decreasing the expression of galectin-3, which is an anti-apoptotic protein overexpressed in ovarian cancer and associated with resistance to chemotherapy. Methods We performed a reverse transfection of miR-424-3p … inform 7 playerWebApr 7, 2003 · This pathway regulates cisplatin sensitivity and is governed by the coordinate activity of six genes associated with ... (2008 and TOV-21G) did not express FANCD2-L (Fig. 1b, lanes 3, 4 ... inform 7 ending the gameWebJan 1, 2024 · The TOV-21G cells were characterized by a different gene expression profile than that used for the SKOV-3 cells. In TOV-21G cells treated with cisplatin alone, only TP53TG5 and CASPASE-8 were up-regulated, while in presence of rhTRAIL alone or combined with cisplatin, CASPASE-8 and BAX were up-regulated and BCL-2 was down … inform 7 automatic mappingWebDuring this sensitization, morin significantly reduces the expression of galectin-3 at the mRNA and protein level, regardless of the presence of cisplatin. Conclusions: Morin sensitizes TOV-21G and SK-OV-3 ovarian cancer cells to cisplatin, what is associated with a decrease of the expression of galectin-3. inform 7 docs